Background Both host and microbe metabolism of tryptophan (Trp) is altered in diabetes; however, the molecular mechanisms are ...

A research group at Nagoya University in Japan has successfully developed an ultrafast and simple synthetic method for producing indole derivatives. Their findings are expected to make drug production ...

A research team has uncovered and rebuilt a previously elusive plant pathway that produces oxindole alkaloids—a rare and ...

Indole, and structures derived from it, are a component of many natural substances, such as the amino acid tryptophan. A new catalytic reaction produces cyclopenta[b]indoles -- frameworks made of ...

Children born to mothers who consume a high-fat, high-sugar diet during pregnancy and breastfeeding face a higher risk of ...

In vivo studies have shown that indole-3-acetic acid is derived from tryptophan by at least two pathways. Tryptophan may undergo transamination to indolepyruvic acid, which in turn is degraded to ...

Indole-based alkaloid natural products such as fischerindoles and hapalindoles have promising antimicrobial and antitumor activities, but they are difficult to make synthetically. New findings on how ...

A cost-effective copper-catalyzed reaction enables selective modification at the C5 position of the indole ring, a backbone for pharmaceutical compounds. Indoles, which form the backbone of many ...

Indole, a molecule made up of a six-membered benzene ring fused to a five-membered ring containing nitrogen, forms the core structure of many biologically active compounds. Derivatives of indole, ...