ctDNA Predicts Overall Survival in Patients With NSCLC Treated With PD-L1 Blockade or With Chemotherapy A next-generation sequencing–based cfDNA assay was used to profile 231 patients with mCRPC from ...
Elimination of autoreactive developing B cells is an important mechanism to prevent autoantibody production. However, how B cell receptor (BCR) signaling triggers apoptosis of immature B cells remains ...
Genetic alterations targeting the PTEN tumor suppressor gene are among the most frequently noted somatic mutations in human cancers. Such lesions have been noted in cancers of the prostate and ...
Imagine that two women have breast cancer with the same subtype: hormone receptor positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-). They’re the same age, weight, and height ...
Yu-Ru Lee, Ming Chen, Jonathan D. Lee, Jinfang Zhang, Shu-Yu Lin, Tian-Min Fu, Hao Chen, Tomoki Ishikawa, Shang-Yin Chiang, Jesse Katon, Yang Zhang, Yulia V. Shulga ...
In this MedPage Today video from the recent San Antonio Breast Cancer Symposium (SABCS), Gaia Griguolo, MD, of the Veneto Institute of Oncology in Padua, Italy, presents findings from a study ...
The PTEN and PI3K-α and -γ are signaling proteins that have important roles in fundamental cellular responses such as proliferation, adhesion, cell size regulation and protection from apoptosis, but ...
Credit: AstraZeneca. The approval was based on data from the phase 3 CAPItello-291 trial, which included patients with HR+/HER2- locally advanced or metastatic breast cancer with PIK3CA/AKT1/PTEN ...
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