Seattle will likely be too tough for the 49ers, and Caleb Williams and the Bears can't expect the Rams to fold like the Packers did.

It's Week 18 of the 2025 NFL season and the regular season comes to a close with plenty to play for around the league. The action starts on Saturday with the Carolina Panthers visiting the Tampa Bay Buccaneers with the NFC South on the line and wraps up Sunday night with the Pittsburgh Steelers hosting the Baltimore Ravens for the AFC North title.

The top seed in the AFC, the Denver Broncos, will face off against the Buffalo Bills this weekend. The results of this weekend's four matchups will determine who will play in the conference championships next week.

The 2026 NFL playoffs roll on with four games in the divisional round, with two on Saturday and two on Sunday. The latest divisional round NFL odds from DraftKings Sportsbook list the Broncos as 1.5-point favorites against the Bills and the Seahawks at -7 against the 49ers on Saturday.

Pregame analysis and predictions of the Buffalo Bills vs. Denver Broncos NFL game to be played on January 17, 2026 on ESPN.