Mitochondrial dysfunction is associated with various chronic diseases and cancers, including neurodegenerative diseases and ...

Prof. Ciro Leonardo Pierri's expertise in structural biology, mitochondrial carrier modeling, and drug targeting—demonstrated ...

The quest for longevity and vitality has captivated humanity for millennia, but only in recent decades has science begun to unravel the biological mechanisms underlying ageing. Today’s anti-ageing ...

Pretzel Therapeutics is advancing its mitochondrial disease therapies, pushing lead candidate PX578 through Phase 1 trials ...

Cirrhotic cardiomyopathy (CCM) is a significant complication of cirrhosis, but its progression and underlying mechanisms ...

The first healthy volunteers have been dosed in an early clinical trial testing NRG5051, a disease-modifying therapy for ALS ...

Reduction in mitochondrial activity in multiple sclerosis contributes to Purkinje cell loss. Researchers at the University of California, Riverside (CA, USA) have demonstrated the role mitochondrial ...

While Alzheimer's Disease is traditionally associated with the buildup of plaques, emerging evidence suggests that mitochondrial dysfunction may play a role in the onset and progression of this ...

Scientists have discovered that boosting the COX7RP protein enhances cellular energy efficiency and significantly extends ...

Mitochondrial respiratory complexes (Complexes I–V) and their assembly into respiratory supercomplexes (SCs) are fundamental to liver bioenergetics, redox homeostasis, and metabolic adaptability.