GPCR dynamics, shown in purple as the human A 2A receptor, and elegant modifications in activation pathways (allostery) indicated by the blue arrow, are critical for enabling GPCRs to bind to multiple ...

Growth factors trigger G proteins (in green) to disengage from GPCRs and change localization within cells. At right: A ribbon diagram of the G protein structure shows the position of all phosphoevents ...

The GPCR-targeting therapies market is expected to grow significantly in the coming years. This is due to the increasing number of patients who are being diagnosed with cancer, the growing awareness ...

Many people are familiar with histamine, a biological molecule, that serves as a key driver of allergic reactions and other immune responses. However ...

G protein-coupled receptors (GPCRs) for hormones and neurotransmitters evolved to be the most important means of communication between cells and tissues in higher organisms. They are responsive to a ...