This article was originally published on www.si.com as Premier League Predictions: Gameweek 22. The domestic cup competitions have stolen attention over the past week but it’s time for the return of the Premier League—and boy are there some cracking fixtures coming up.

The 2025-26 Premier League season is past its mid-point but there are still so many questions regarding the quality and realistic fates of almost every club.

Who's leading after MD21? And what do our writer, the algorithm, a child and this week's subscriber expect to see on Matchday 22?

Man Utd predicted lineup vs. Man City (4-2-3-1): Lammens; Dalot, Maguire, Martínez, Shaw; Mainoo, Casemiro; Mbeumo, Fernandes, Cunha; Šeško. City ’s stack of defensive injuries remains a problem, although Guardiola’s makeshift unit performed well at Newcastle in the week.

Brandon's DraftKings and FanDuel EPL DFS lineup picks for English Premier League Soccer on 1/17/26 (Matchweek 22). His top daily fantasy soccer forwards, midfielders, defenders, goalkeepers.

Each week, we'll be bringing you a selection of games that we think could go against the grain and see an underdog surprise a fancied foe

Burnley predicted lineup vs. Liverpool (3-4-2-1): Dúbravka; Laurent, Estève, Humphreys; Walker, Ugochukwu, Florentino, Pires; Edwards, Anthony; Broja. Liverpool continue to look unconvincing, even in victory, but they should have enough firepower to conquer a Burnley side that has lost nine of the last 12 Premier League matches.

Alan Shearer has provided us with his latest round of Premier League predictions ahead of this weekend’s action. Af

Gameweek 22 of the Premier League season brings a full schedule of fixtures with plenty of attacking opportunities and favorable matchups. With injuries, rotation risk, and form all factored in, below are our top FPL player picks for Gameweek 22 — from starting XI essentials to differential options.